The “female infidelity” gene refers to five genetic variants of the AVPR1A gene. The AVPR1A gene encodes the arginine vasopressin receptor 1A, which binds vasopressin and transmits the signal into the cells.

Vasopressin is a hormone or “chemical messenger” that promotes water retention in the kidneys and increases blood pressure. Most of these effects take place when vasopressin is released into the blood stream. However, when vasopressin is released directly into the brain, it can influence social and sexual behavior (such as infidelity).